Methylprednisolone alone or combined with cyclosporine or mycophenolate mofetil for the treatment of immune‐mediated hemolytic anemia in dogs, a prospective study

• DOI: 10.1111/jvim.17122
• Publication Date: 2024-07-04T04:40:03Z
• Authors: Chiara Agnoli; Michele Tumbarello; Kateryna Vasylyeva; Carola S. Selva C...; Erika Monari; Marta Gruarin; Roberta Troìa; Francesco Dondi
• Keywords: Mycophenolate

Abstract Background Benefit of adding a second‐line immunosuppressive drug to glucocorticoids for the treatment non‐associative immune‐mediated hemolytic anemia (naIMHA) in dogs has not been defined prospectively. Hypothesis/Objectives Evaluate effectiveness different protocols naIMHA dogs. Animals Forty‐three client‐owned Methods Open label, randomized, clinical trial. Dogs were treated with methylprednisolone (M‐group), plus cyclosporine (MC‐group) or mycophenolate mofetil (MM‐group). as responders by disappearance signs destruction and hematocrit stabilization. Frequency was compared between M‐group combined (MC MM‐group evaluated together), among 3 therapeutic groups at 14 (T14), 30 (T30), 60 (T60) days after admission. complications, length hospitalization relapse also compared. Death rate discharge, T60 365 (T365) days. Results Proportion significantly MM‐groups), nor T14, T30, ( P > .17 ). relapse, protocols, (P .22). more common only MC‐group (+42.8%; 95% CI: 11.5–67.4; = .009), T365 (+50%; 17.5–73.2; .003). Conclusions Clinical Importance Combined therapy did improve hematological response naIMHA.