Familial osteochondrodysplastic and cardiomyopathic syndrome in Chianina cattle

• DOI: 10.1111/jvim.17221
• Publication Date: 2024-10-26T17:04:03Z
• Authors: Joana G. P. Jacinto; Tolulope G. Ogundipe; Cinzia Benazzi; Irene M. Häfliger; Luisa V. Muscatello; Marilena Bolcato; Riccardo Rinnovati; Arcangelo Gentile; Cord Drögemüller
• Keywords: osteochondrodysplastic; cardiomyopathic; genetic; Chianina cattle; FOOD ANIMAL; bovine; precision medicine; recessive disorders; Veterinary medicine; SF600-1100; lethal allele frequency; inbreeding

Skeletal dysplasia encompasses a heterogeneous group of genetic disorders characterized by an abnormal development bones, joints, and cartilage. Two Chianina half-sibling calves from consanguineous mating with congenital skeletal malformations cardiac abnormalities were identified.