Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in freshwater crocodiles (Crocodylus siamensis) after intravenous and intramuscular administration

• DOI: 10.1111/jvp.12791
• Publication Date: 2019-07-04T17:18:38Z
• Authors: Saranya Poapolathep; Mario Giorgi; Narongsak Chaiyabutr; Chanat Chokejaroe...; Narumol Klangkaew; Napasorn Phaochoosak; Tara Wongwaipairote; Amnart Poapolathep
• Keywords: Active metabolite; Crocodylus; Dextrorphan

Abstract To the best of authors’ knowledge, pharmacokinetic information to establish suitable therapeutic plans for freshwater crocodiles is limited. Therefore, purpose this study was clarify characteristics enrofloxacin (ENR) in crocodiles, Crocodylus siamensis , following single intravenous and intramuscular administration at a dosage 5 mg/kg body weight (b.w.). Blood samples were collected assigned times up 168 hr. The plasma concentrations ENR its metabolite ciprofloxacin (CIP) measured by liquid chromatography tandem–mass spectrometry. CIP quantified 144 hr after both administrations. half‐life long (43–44 hr) similar absolute i.m. bioavailability 82.65% binding percentage protein ranged from 9% 18% with an average 10.6%. Percentage (plasma concentrations) 15.9% 19.9% i.v. administration, respectively. Based on data, susceptibility break point PK‐PD indexes, b.w. might be appropriate treatment susceptible bacteria (MIC > 1 μg/mL) C. .