Pharmacokinetics and residue elimination of norfloxacin in rainbow trout (Oncorhynchus mykiss)

• DOI: 10.1111/jvp.13046
• Publication Date: 2022-02-28T11:24:06Z
• Authors: Zhuoqun Wang; Yan Yang; Yingchun Mu; Bo Liu; Pei Zhang; Xin Zhang; Huiwu Sun; Yi Song; Bo Cheng
• Keywords: Residue (chemistry)

We studied the metabolism and elimination of norfloxacin in rainbow trout (Oncorhynchus mykiss) following a single oral administration 50 mg/kg at 15 ± 2°C. Norfloxacin was measured by high-performance liquid chromatography-tandem mass spectrometry plasma, muscle, liver, kidney, skin remainder tissues, concentrationtime curve characterized double peak. The drug absorbed rapidly; first peak appeared within 4 h, second 24 h all substrates tested. maximal concentrations liver kidney were 0.468 mg/L, 14.146 mg/kg, 6.445 0.977 respectively. distribution half-life 5.814, 9.026, 17.027 1.004 41.205, 41.667, 44.896 54.908 Using as reference tissue for monitoring aquaculture 2 μg/kg maximum residue limit standard, it takes 555 temperature-day (°C days) to be completely eliminated from trout.