Abnormal regional homogeneity of resting‐state brain activity in patients with HBV‐related cirrhosis without overt hepatic encephalopathy

• DOI: 10.1111/liv.12096
• Publication Date: 2012-12-24T05:12:46Z
• Authors: Xiao‐Fei Lv; Ying‐Wei Qiu; Jun‐Zhang Tian; Chuan‐Miao Xie; Lu‐Jun Han; Huan‐Huan Su; Zhen‐Yin Liu; Jun‐Ping Peng; Chu‐Lan Lin; Mao‐Sheng Wu; Gui‐Hua Jiang; Xue‐Lin Zhang
• Keywords: Precentral gyrus; Hepatic Encephalopathy; Lingual gyrus

Many studies have reported that cognitive deficits exist in cirrhotic patients without overt hepatic encephalopathy (OHE). However, the neurobiological mechanisms underlying these are still not fully understood.To investigate regional activity abnormalities with hepatitis B virus-related cirrhosis (HBV-RC) OHE using resting-state functional MRI (Rs-fMRI), and to examine relationship between impaired cognition.A newly homogeneity (ReHo) approach was used compare local synchronization of Rs-fMRI signals 32 HBV-RC well-matched healthy controls. Cognition measured all psychometric score (PHES) tests, ReHo variation PHES analysed.Relative controls, group showed high prefrontal cortex, widespread low visual association areas (left lingual gyrus, middle temporal gyrus right occipital gyrus), motor (bilateral precentral paracentral lobule) bilateral precuneus. Correlation analysis mean values different brain revealed a significantly positive correlation left (r = 0.352; P 0.048), 0.453; 0.009) (left: r 0.436, 0.013; right: 0.582, < 0.001), lobule 0.485; 0.005) precuneus 0.468; 0.007).Our results provide information on pathophysiological alterations demonstrate feasibility as noninvasive modality which detect progression changes patients.