A nationwide seroepidemiology of hepatitis C virus infection in South Korea
hepatitis C virus
Adult
Male
570
prevalence
Hepacivirus/genetics
610
Hepacivirus
Hepatitis C/diagnosis*
Viral/blood
Antiviral Agents
Hepatitis C/drug therapy
Young Adult
03 medical and health sciences
Age Distribution
0302 clinical medicine
Hepatitis C Antibodies/blood*
Residence Characteristics
Seroepidemiologic Studies
Hepatitis C/blood
616
Republic of Korea
Prevalence
Humans
Sex Distribution
Aged
Antiviral Agents/therapeutic use
360
Korea
Chi-Square Distribution
Hepacivirus/immunology*
Hepatitis C/epidemiology*
Hepatitis C Antibodies
Middle Aged
Health Surveys
Hepatitis C
infection
3. Good health
Treatment Outcome
RNA
RNA, Viral
Female
Republic of Korea/epidemiology
Biomarkers/blood
Biomarkers
DOI:
10.1111/liv.12108
Publication Date:
2013-01-04T15:20:55Z
AUTHORS (33)
ABSTRACT
AbstractBackground & AimsThe aim of this study was to reveal nationwide seroprevalence of HCV infection in South Korea by a large‐scale survey.MethodsFrom January to December 2009, a total of 291 314 adults underwent health check‐up in 29 centres nationwide. The data concerning anti‐HCV antibody and biochemical tests were obtained from all participants. Among subjects with positive anti‐HCV, such data as HCV RNA, genotypes and treatment detail were additionally analysed.ResultsUsing an estimated 2009 population of Korea, the age, sex and area‐adjusted anti‐HCV positive rate was 0.78%. Anti‐HCV prevalence in female patients (0.83%) was higher than that in male patients (0.75%). Gradual increase in anti‐HCV positivity was observed, from 0.34% in those aged 20–29 years to 2.31% in those >70 years. The age‐ and sex‐adjusted anti‐HCV prevalence varied in different areas, being higher in Busan and Jeonnam (1.53–2.07%), mid‐level in Seoul and surrounding districts (0.50–0.61%) and lower in Jeju (0.23%). The comparative analysis of laboratory variables between anti‐HCV (+) and anti‐HCV (−) group revealed significantly higher levels of alanine aminotransferase and lower levels of serum lipids in anti‐HCV (+) group. Among 1 718 anti‐HCV positive subjects, serum HCV RNA was measured only in 478 people, of whom 268 (56.1%) patients had detectable HCV RNA in serum. Among 50 patients for whom assessment of response to antiviral therapy was feasible, overall sustained virological response was achieved in 84% of patients.ConclusionThe prevalence of HCV infection is low in South Korea. Studies to analyse risk factors are warranted to reduce HCV infection.
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