Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis

• DOI: 10.1111/liv.12685
• Publication Date: 2014-09-15T05:39:32Z
• Authors: Kazutoshi Yamada; Eishiro Mizukoshi; Hajime Sunagozaka; Kuniaki Arai; Tatsuya Yamashita; Yumie Takeshita; Hirofumi Misu; Toshinari Takamura; Seiko Kitamura; Yoh Zen; Yasuni Nakanuma; Masao Honda; Shuichi Kaneko
• Keywords: Nonalcoholic steatohepatitis; Steatohepatitis; Steatosis

Nonalcoholic fatty liver disease (NAFLD) is closely related to insulin resistance and lipid metabolism. Recent studies have suggested that the quality of fat accumulated in associated with development nonalcoholic steatohepatitis (NASH). In this study, we investigated acid composition tissue its association pathology NAFLD patients.One hundred three patients diagnosed [simple steatosis (SS): 63, NASH: 40] were examined their hepatic acids measured using gas chromatography. addition, relationships between ratios various patient backgrounds, laboratory test values, histology liver, expression metabolism-related enzymes investigated.The C16:1n7 content, C16:1n7/C16:0 C18:1n9/C18:0 increased C18:0/C16:0 ratio was decreased NASH group. The score tissue, lobular inflammation score. expressions levels genes: SCD1, ELOVL6, SREBP1c, FAS PPARγ enhanced multivariate analysis, most important factor correlated contrast, inflammation.The genes metabolism different SS groups, suggesting acceleration deeply involved pathogenesis NASH.