Viral genotype correlates with distinct liver gene transcription signatures in chronic hepatitis C virus infection

• DOI: 10.1111/liv.12830
• Publication Date: 2015-03-20T16:10:45Z
• Authors: Mark W. Robinson; Elihu Aranday‐Cortes; Derek Gatherer; Rachael Swann; Jolanda M. P. Lie...; Ana Da Silva Filipe; Alex Sigruener; Stephen T. Barclay; Peter R. Mills; Arvind H. Patel; John McLauchlan
• Keywords: Liver disease; Chronic infection

Chronic hepatitis C virus (HCV) infection of the liver with either genotype 1 or 3 gives rise to distinct pathologies, and two viral genotypes respond differently antiviral therapy.To understand these clinical differences, we compared gene transcription profiles in biopsies from patients infected gt1 gt3, uninfected controls.Gt1-infected displayed elevated levels transcripts regulated by type I III interferons (IFN), including genes that predict response IFN-α therapy. In contrast, controlled IFN-γ were induced gt3-infected biopsies. Moreover, higher Analysis hepatocyte-derived cell lines confirmed upregulated gt3 preferentially IFN-γ. The transcriptional profile was unaffected IFNL4 polymorphisms, providing a rationale for reduced predictive power IFNL genotyping patients.The interactions between HCV hepatocytes are distinct. These unique provide avenues explore biological mechanisms drive genotype-specific differences disease progression treatment response. A greater understanding host-pathogen different is required facilitate optimal management infection.