Nonalcoholic steatohepatitis is associated with a higher risk of advanced colorectal neoplasm

• DOI: 10.1111/liv.14163
• Publication Date: 2019-06-04T12:01:27Z
• Authors: Yuri Cho; Soo‐Kyung Lim; Sae Kyung Joo; Dong‐Hyong Jeong; Jung Ho Kim; Jeong Mo Bae; Jeong Hwan Park; Mee Soo Chang; Dong Hyeon Lee; Yong Jin Jung; Byeong Gwan Kim; Donghee Kim; Kook Lae Lee; Won Kim
• Keywords: Adult; Liver Cirrhosis; Male; 0301 basic medicine; Biopsy; Colonoscopy; Middle Aged; 3. Good health; 03 medical and health sciences; Logistic Models; Liver; Non-alcoholic Fatty Liver Disease; Risk Factors; Republic of Korea; Prevalence; Humans; Female; Prospective Studies; Registries; Colorectal Neoplasms; Aged

Abstract Background & Aims Nonalcoholic fatty liver disease (NAFLD) is known to increase the risk of adenomatous colonic polyps. However, role screening colonoscopy in patients with biopsy‐proven NAFLD detecting advanced colorectal neoplasm not clearly evidence‐based. Therefore, we investigated whether histological severity associated neoplasm. Methods This study included ≥18 years old who underwent between 2013 and 2018 within a biopsy‐evaluated prospective cohort. Advanced was defined as an polyp greater than 10 mm diameter and/or villous histology high‐grade dysplasia or adenocarcinoma. Results Among 476 clinically suspected NAFLD, 379 were diagnosed 97 had no evidence histologically, analyzed healthy controls. The prevalence 11.1% (n = 53). Patients higher grade steatosis ( P 0.004) stage hepatic fibrosis 0.044) those normal colonoscopic findings low‐grade polyp. Multivariable logistic regression analysis revealed that presence nonalcoholic steatohepatitis (NASH) independent factor for both (odds ratio [OR], 2.08; 95% confidential interval [CI], 1.12‐3.86; 0.020) (OR, 2.81; CI, 1.01‐7.87; 0.049). Conclusions NASH significantly increased among NAFLD. finding may alert physicians conduct detect early.