Polycystic ovary syndrome (PCOS) is associated with NASH severity and advanced fibrosis

• DOI: 10.1111/liv.14279
• Publication Date: 2019-10-18T21:58:47Z
• Authors: Monika Sarkar; Norah Terrault; Wesley Chan; Marcelle I. Cedars; Heather G. Huddle...; Caroline C. Duwaerts; Dana Balitzer; Ryan M. Gill
• Keywords: Steatohepatitis; Steatosis

Abstract Background Polycystic ovary syndrome (PCOS) affects 10% of reproductive‐aged women, and is marked by irregular menses high androgens. PCOS a known risk factor for imaging‐confirmed steatosis, we now aim to evaluate whether influences histologic severity non‐alcoholic fatty liver disease (NAFLD). Methods Retrospective study women ages 18‐45 years with biopsy‐confirmed NAFLD between 2008 2019. Metabolic comorbidities were captured within 6 months biopsy. Histologic features steatohepatitis (NASH) independently evaluated two pathologists blinded status. Results Among 102 meeting criteria, 36% (n = 37) had PCOS; median age was 35 years; 27% white, 6% black, 19% Asian 47% reported Hispanic ethnicity. Women higher LDL (122 vs mg/dL, P .05) body mass index(BMI) (38 33 kg/cm 2 , < .01). NASH present in 76% 66% without ( .3), proportion severe ballooning (32% 13%, .02), presence any fibrosis (84% 66%, .06) advanced (16% 6%, .10). Adjusted BMI, remained associated hepatocyte (OR 3.4, 95% CI 1.1‐10.6, .03) 7.1, 1.3‐39, .02). fibrosis, 5 younger those as compared (40 45 years, Conclusion more NASH, including fibrosis. Hepatologists should routinely inquire about NAFLD, this population.