Development of Liver‐Heart Score for Early Detection of Myocardial Contractile Dysfunction in Cirrhosis by Strain Imaging

• DOI: 10.1111/liv.70062
• Publication Date: 2025-03-19T13:09:01Z
• Authors: Marcel Razpotnik; Simona Bota; Philipp Wimmer; Peter Hofer; Michael Hackl; Matthias Fürstner; Hannes Alber; Raphael Mohr; Alexander Wree; Nirbaanjot Walia; Cornelius Engelmann; Münevver Demir; Frank Tacke; Markus Peck‐Rados...
• Keywords: Contractility; Dilated Cardiomyopathy

ABSTRACT Aim Cirrhotic cardiomyopathy is characterised by myocardial dysfunction in patients with cirrhosis the absence of other cardiac conditions. We aimed to develop and validate a scoring system identify at high risk for reduced global longitudinal strain, newly proposed marker updated diagnostic criteria cirrhotic cardiomyopathy. Methods Prospectively recruited training validation groups underwent identical hepatological cardiological evaluations, including strain echocardiography. Risk factors were identified using logistic regression. Results In cohort 452 consecutive patients, 278 excluded due non‐cirrhotic or conditions potentially affecting measurements. The prevalence was 9.8% (13/133) group 19.5% (8/41) group. Multivariate regression revealed BMI ≥ 28 kg/m 2 (OR 7.02), CAP > 260 dB/m 8.53), age 57 years 4.68) as independent predictors contractility. These variables combined weighted based on their beta coefficients Liver‐heart score (CAP [2 pts], [1 pt]). AUC‐ROC 0.84 0.83 cohort. A 5 points associated increased mortality, observed (44.4% vs. 17.3%) end follow‐up period (66.7% 37.7%, HR 1.3, p < 0.01). Conclusion can accurately rule out contractility may be useful stratification patients.