Initial Use of High‐Dose Anticholinergics Combined with Alpha‐Blockers for Male Lower Urinary Tract Symptoms with Overactive Bladder: A Prospective, Randomized Preliminary Study

Solifenacin Tamsulosin Tolterodine Urinary urgency
DOI: 10.1111/luts.12124 Publication Date: 2016-03-30T23:10:46Z
ABSTRACT
Objectives To evaluate the clinical efficacy of initial combined treatment alpha‐blocker plus dose‐dependent anticholinergic agent compared to monotherapy in benign prostatic hyperplasia patients with overactive bladder. Methods Male lower urinary tract symptoms ( LUTS ) International Prostate Symptom Score IPSS 8 or higher, total bladder OABSS 3 and 2 points higher questionnaire number were enrolled. Eligible subjects (total n = 146) randomly assigned receive tamsulosin 0.2 mg (Group I, 44), solifenacin 5 II , 55), 10 III 47) for 12 weeks. Efficacy safety assessments each group done using detailed questionnaires, evaluating parameters such as maximal flow rate Qmax postvoid residual volume PVR at 4 Results Groups (combined use solifenacin) showed significant improvement storage I (tamsulosin monotherapy), reflected by subscore P < 0.05). Dry mouth developed four (7%) eight (17%) cases respectively, so that one (2%) three (6%) dropped out respectively. Two (4%) AUR them was withdrawn from study. Conclusions Initial men improves significantly, but dose modification is necessary prevent adverse events.
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