In Candida albicans hyphae, Sec2p is physically associated with SEC2 mRNA on secretory vesicles

• DOI: 10.1111/mmi.12799
• Publication Date: 2014-09-18T07:37:50Z
• Authors: David Caballero‐Lima; Guillaume M. Haut...; Stuart A. Wilson; Peter E. Sudbery
• Keywords: Secretory Vesicle; Rab; Secretory protein

Candida albicans hyphae grow in a highly polarized fashion from their tips. This growth requires the continuous delivery of secretory vesicles to tip region. Vesicle depends on Sec2p, Guanine Exchange Factor (GEF) for Rab GTPase Sec4p. GTP bound Sec4p is required transit trans-Golgi sites growth. We previously showed that phosphorylation Sec2p at residue S584 was necessary support hyphal, but not yeast Here we show SEC2 mRNA physically associated with Sec2p. Moreover, allows dissociate and speculate this function and/or translation. During hyphal extension, growing may be separated nucleus by up 15 μm. Transport localizes translation allowing sufficient accumulation key protein site