Lactobacillus gasseri and Gardnerella vaginalis produce extracellular vesicles that contribute to the function of the vaginal microbiome and modulate host–Trichomonas vaginalis interactions

Gardnerella vaginalis Lactobacillus gasseri
DOI: 10.1111/mmi.15130 Publication Date: 2023-07-24T08:13:20Z
ABSTRACT
Abstract Trichomonas vaginalis is an extracellular protozoan parasite of the human urogenital tract, responsible for a prevalent sexually transmitted infection. Trichomoniasis accompanied by dysbiotic microbiome that characterised depletion host‐protective commensals such as Lactobacillus gasseri , and flourishing bacterial consortium comparable to one seen vaginosis, including founder species Gardnerella . These two vaginal bacteria are known have opposite effects on T. pathogenicity. Studies vesicles (EVs) been focused direction microbial producer (commensal or pathogen) host recipient, largely in context gut microbiome. Here, taking advantage simplicity cervicovaginal microbiome, we determined molecular cargo EVs produced L. G. examined how these modulate interaction cells. We show carry specific proteins, which functions can be attributed roles play biome. Furthermore, delivered cells, modulating host‐pathogen interactions way mimics This first study describe side‐by‐side protein composition belonging spectrum demonstrate pathogenicity parasite. Such trichomoniasis, infections dysbiosis co‐occur frequently resulting significant co‐morbidities. Therefore, studies like this provide knowledge development antimicrobial therapies aim clear infection while restoring healthy
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