Levels of interleukin (IL)‐6 and IL‐8 are elevated in serum and bronchoalveolar lavage fluid of haematological patients with invasive pulmonary aspergillosis

• DOI: 10.1111/myc.12679
• Publication Date: 2017-09-06T16:58:41Z
• Authors: Sven Heldt; Susanne Eigl; Juergen Prattes; Holger Flick; Jasmin Rabensteiner; Florian Prüller; Tobias Niedrist; Peter Neumeister; Albert Wölfler; Heimo Strohmaier; Robert Krause; Martin Hoenigl
• Keywords: Adult; Male; 0301 basic medicine; Clinical Sciences; Clinical sciences; Microbiology; 03 medical and health sciences; Rare Diseases; Clinical Research; IL-17A; Humans; haematological malignancy; Lung; IFN-γ; Aged; Retrospective Studies; BAL; Invasive Pulmonary Aspergillosis; Biomedical and Clinical Sciences; Interleukin-6; Interleukin-8; Middle Aged; Hematologic Diseases; 3. Good health; IFN-; Infectious Diseases; Aspergillus; IL-10; Female; serum; Bronchoalveolar Lavage Fluid; Biomarkers

Aspergillus spp. have been shown to induce T-helper cell (Th) 1 and Th17 subsets resulting in elevated levels of several cytokines. The objective this study was analyse a bundle cytokines serum bronchoalveolar lavage fluid (BALF) patients with without invasive pulmonary aspergillosis (IPA). This nested case-control analysis included 10 probable/proven IPA 20 matched controls evidence IPA, out pool prospectively enrolled (2014-2017) adult cases underlying haematological malignancies suspected infection. Serum samples were collected within 24 hours BALF sampling. All stored at -70°C for retrospective determination IL-6 IL-8 significantly associated both (P = .011 P .028) .006 .012, respectively), trend observed IL-10 .059). In multivariate conditional logistic regression analysis, remained significant predictor among conclusion, similar IL-10. Future cohort studies should determine the diagnostic potential these evaluate combinations other biomarkers/diagnostic tests.