Epidemiology of fungaemia in Sweden: A nationwide retrospective observational survey

• DOI: 10.1111/myc.12816
• Publication Date: 2018-06-19T20:13:35Z
• Authors: Lena Klingspor; Måns Ullberg; Johan Rydberg; Nahid Kondori; Lena Serrander; Jonas Swanberg; Kenneth Nilsson; Cecilia Jendle Be...; Marcus Johansson; Margareta Granlund; Eva Törnqvist; Anders Nyberg; Karin Kindlund; Minna Ygge; Dalila Kartout‐Bo...; Michael Toepfer; Eva Hålldin; Gunnar Kahlmeter; Volkan Özenci
• Keywords: Adult; Aged, 80 and over; Male; 0303 health sciences; Antifungal Agents; Adolescent; Incidence; Infant, Newborn; Candidemia; Infant; Microbial Sensitivity Tests; Middle Aged; Meningitis, Fungal; 3. Good health; 03 medical and health sciences; Drug Resistance, Fungal; Child, Preschool; Humans; Female; Child; Aged; Candida; Retrospective Studies

SummaryObjectivesTo identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates to identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates in Sweden.MethodsThe study was a retrospective, observational nationwide laboratory‐based surveillance for fungaemia and fungal meningitis and was conducted from September 2015 to August 2016.ResultsIn total, 488 Candida blood culture isolates were obtained from 471 patients (58% males). Compared to our previous study, the incidence of candidaemia has increased from 4.2/100 000 (2005‐2006) to 4.7/100 000 population/year (2015‐2016). The three most common Candida spp. isolated from blood cultures were Candida albicans (54.7%), Candida glabrata (19.7%) and species in the Candida parapsilosis complex (9.4%). Candida resistance to fluconazole was 2% in C. albicans and between 0% and 100%, in non‐albicans species other than C. glabrata and C. krusei. Resistance to voriconazole was rare, except for C. glabrata, C. krusei and C. tropicalis. Resistance to anidulafungin was 3.8% while no Candida isolate was resistant to amphotericin B.ConclusionsWe report an overall increase in candidaemia but a minor decrease of C. albicans while C. glabrata and C. parapsilosis remain constant over this 10‐year period.