Perturbations of immune landscape in COVID‐19 associated mucormycosis

• DOI: 10.1111/myc.13546
• Publication Date: 2022-11-16T07:24:10Z
• Authors: Nidhi Desai; Vandana Pradhan; Durga Chougule; Smrati Tiwari; Charuta Mandke; Reetika Malik Yadav; Amita Athvale; Juhi Kawle; Vinayak Pai; Swapnal Pawaskar; Harshada Kharkar; Snehal Bhosale; Ankita Parab; Shazia Ansari; Kinnera Harish Kumar; Shashikant Mhashal; Neelam Redkar; Manisha Madkaikar
• Keywords: Immunophenotyping

A rise in secondary fungal infections during the COVID-19 pandemic necessitates a deeper understanding of associated immunological perturbations.To evaluate clinical and characteristics observed patients with mucormycosis (CAM) infection.Cases or post-COVID-19 infection were compared cases acute convalescent COVID-19. Lymphocyte subsets, cytokines other laboratory markers between groups.The frequency proposed risk factors for CAM was diabetes mellitus (77%), recent history steroid use (69%) hypoxia (52%). Iron metabolism dysregulated low TIBC total iron. Further, accompanied lymphopenia drastic reduction B cell counts; however, plasmablasts not altered. had immunoglobulin levels antibodies specific to mucor peptide did increase suggesting dysfunction B-cell response. There activated effector cytotoxic CD8 T cells NK healthy controls. Among helper cells, Tregs reduced Th-1 increased infection. distinct cytokine signature evident IL-1β, IFN-γ, IL-6, IL-22, IL-17A, IL-10, IL-2, IL-8, IL-7, IL-21 GM-CSF.This is first study on immunophenotyping need long-term monitoring function after SARS-CoV-2 glycaemic control possible benefit therapeutic supplementation intravenous immunoglobulins CAM.