Cysteine‐rich protein 61, a specific ultra‐early biomarker in kidney ischemia/reperfusion injury

• DOI: 10.1111/nep.13513
• Publication Date: 2018-10-17T08:32:44Z
• Authors: Chenyu Li; Long Zhao; Yanfei Wang; Lin Che; Hong Luan; Congjuan Luo; Yan Xu
• Keywords: CYR61

ABSTRACT Aim Studies have shown that cysteine‐rich protein 61 (Cyr61) increased in the post‐ischemic human kidney tissue. However, it is still unknown whether Cyr61 can be used as a biomarker ischemia/reperfusion (I/R) injury. Methods Microarray data were collected from GSE58438 and GSE52004. The rat I/R model was established to evaluate messenger RNA expression of Cyr61, localization by immunohistochemical immunofluorescence staining, changes serum creatinine (Scr) at same time. Results Bioinformatics result showed significantly 3 h after kidney, involved angiogene, positive regulation locomotion single organism cell adhesion. results mainly expressed renal tubular epithelial cells with injury up‐regulated 1 h, peaked 4–8 began decay 12 h. area under curve receiver operating characteristics tissue urine 90.2% 86.1%, which all better than Scr 67.1% ( P < 0.05). Conclusion We made preliminary investigation relationship between AKI, identifies may replace an ultra‐early new AKI.