Clinical features and outcomes of kidney transplant recipients with focal segmental glomerulosclerosis recurrence

• DOI: 10.1111/nep.13589
• Publication Date: 2019-03-20T04:35:45Z
• Authors: Juliana B Mansur; Tainá V Sandes‐Fr...; Gianna M Kirsztajn; Marina P Cristelli; Gustavo F Mata; Mayara I de Paula; Patricia C Grenzi; Suelen B S Martins; Claudia R Felipe; Hélio Tedesco‐Silva; José O M Pestana
• Keywords: Plasmapheresis; Single Center

ABSTRACT Aim Focal segmental glomerulosclerosis recurs in up to 30% and 80% of adult pediatric kidney transplant recipients, respectively. There is no standard care treatment. The purpose this study was evaluate clinical characteristics, treatments outcomes patients with focal recurrence (FSGSr). Methods This a retrospective single‐center cohort including FSGSr treated plasmapheresis (PP) combinations high dose steroids, cyclosporine rituximab. Results Among 61 included analysis the median time diagnosis 19 days. incidence first biopsy‐confirmed 18% reaching 52.4% follow‐up biopsies. During PP treatment 54% developed infectious complications. discontinued 37% due failure (no remission or graft loss) 26% an adverse event. All who event did not show response lost allograft. acute rejection 34.4%. incidences partial complete remissions were 16.4% 27.8%, Overall 6‐years patient survivals 90.7% 64.5%, Conclusion confirms low, variable unpredictable rate remission, inconsistencies among available therapeutic options its events, negative impact on survival.