Increased Subthalamic Nucleus Deep Brain Stimulation Amplitude Impairs Inhibitory Control of Eye Movements in Parkinson's Disease

• DOI: 10.1111/ner.13476
• Publication Date: 2021-06-17T16:36:21Z
• Authors: Miranda J. Munoz; Lisa C. Goelz; Gian D. Pal; Jessica A. Karl; Leo Verhagen Metman; Sepehr Sani; Joshua M. Rosenow; Jody D. Ciolino; Ajay S. Kurani; Daniel M. Corcos; Fabian J. David
• Keywords: Subthalamic Nucleus; Inhibitory control

Bilateral subthalamic nucleus deep brain stimulation (STN DBS) in Parkinson's disease (PD) can have detrimental effects on eye movement inhibitory control. To investigate this effect of bilateral STN DBS, we examined the manipulating DBS amplitude control during antisaccade task. The prosaccade error rate task, that is, directional errors, was indicative impaired We hypothesized as increased, would increase.Ten participants with completed task six different amplitudes (including zero amplitude) after a 12-hour overnight withdrawal from antiparkinsonian medication.We found increased (p < 0.01). Additionally, modeled volume tissue activated (VTA) and overlap decreased, but relationship depended = 0.04).Our findings suggest higher settings be modulatory for Some individual variability explained by active contact location VTA-STN overlap. Higher are more deleterious if contacts fall outside resulting smaller This is clinically significant it inform clinical optimization parameters. Further studies needed to determine other aspects cognition whether deficits result meaningful impact quality life.