Medial temporal regional argyrophilic grain as a possible important factor affecting dementia in Parkinson's disease

• DOI: 10.1111/neup.12208
• Publication Date: 2015-06-16T10:05:15Z
• Authors: Taku Homma; Yoko Mochizuki; Kazushi Takahashi; Takashi Komori
• Keywords: Cerebral Cortex; Male; Parkinson Disease; Middle Aged; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; alpha-Synuclein; Humans; Dementia; Female; Phosphorylation; Aged

Argyrophilic grain (ArG) is the main pathological feature of argyrophilic disease (AGD) and clinically characterized by cognitive impairment, behavioral abnormalities, personality changes, emotional imbalances. However, ArG can not only be found in AGD but also various other neurological disorders, including Parkinson's (PD). The association with psychosis and/or dementia disorders remains unknown; this study, we have investigated PD. distribution degree deposition, spongiform change transentorhinal cortex (TER SpC), phosphorylated alpha-synuclein-positive neurites CA2/3 were assessed, used formalin-fixed, paraffin-embedded specimens obtained from anterior/posterior medial temporal region 20 autopsy cases diagnosed as These divided into two groups: PD without (PDND) (PDD). Most PDD revealed scattered to numerous or moderate severe TER SpC, both which rarely observed PDND group. Furthermore, density group was further three subtypes: ArG, SpC ArG/TER SpC. Scattered-to-numerous moderate-to-severe PDD, suggested that could important factors affecting their are equally important.