Primary epithelial‐myoepithelial carcinoma of the pituitary gland

• DOI: 10.1111/neup.12628
• Publication Date: 2020-01-04T05:15:45Z
• Authors: Victoria Lavin; Fabio Callipo; Carmine A. Donofrio; Rhianedd Ellwood‐...; Robert Metcalf; Ibrahim Djoukhadar; Claire E. Higham; Tara Kearney; Rovel Colaco; Kanna Gnanalingham; Federico Roncaroli
• Keywords: 03 medical and health sciences; 0302 clinical medicine; epithelial-myoepithelial carcinoma; pituitary gland; salivary gland-like tumors; 3. Good health

Primary salivary gland‐like tumors of the sella are rare and often challenging to diagnose. They reportedly derive from serous mucinous glands that remain trapped in infundibulum during embryogenesis. We report a 68‐year‐old man who presented with partial left third cranial nerve palsy, visual loss eye without field defects, headache, weight reduced muscle bulk. Neuroimaging studies demonstrated solid cystic, avidly enhancing lesion expanding pituitary fossa extending cavernous sinus. The patient underwent craniotomy tissue removed showed features epithelial‐myoepithelial carcinoma similar gland, skin breast counterpart. No primary tumor was found outside sella. behaved aggressively despite radio‐chemotherapy died 22 months onset. novel TP53 in‐frame deletion (Gly154del) while no variants were H‐RAS hotspot regions (codons 12, 13 61). Our expands spectrum primarily occurring emphasizes need for specialist review rare, non‐neuroendocrine regions.