Gastric electrical stimulation with Enterra therapy improves symptoms of idiopathic gastroparesis

• DOI: 10.1111/nmo.12185
• Publication Date: 2013-07-30T01:51:04Z
• Authors: R. W. McCallum; I. Sarosiek; H. P. Parkman; W. Snape; F. Brody; J. Wo; T. Nowak
• Keywords: Gastroparesis; Crossover study

Abstract Background Gastric electrical stimulation ( GES ) is a therapeutic option for intractable symptoms of gastroparesis GP ). Idiopathic ID ‐ represents subset . AIMS : A prospective, multicenter, double‐blinded, randomized, crossover study to evaluate the safety and efficacy Enterra in treatment chronic vomiting Methods Thirty‐two subjects (mean age 39; 81% F, mean 7.7 years were implanted with The stimulator was turned ON 1½ months followed by double‐blind randomization consecutive 3‐month periods device either or OFF unblinded fashion another 4.5 months. Twenty‐five completed phase 21 finished 1 year follow‐up. Key Results During period, there reduction weekly frequency WVF from baseline (61.2%, P < 0.001). There non‐significant between vs (the primary outcome) median 17% (P > 0.10). Seventy‐five percent patients preferred period = 0.021). At year, remained decreased (median 87%, 0.001), accompanied improvements symptoms, gastric emptying days hospitalization 0.05). Conclusions & Inferences (i) In this prospective , during initial period; (ii) showed outcome variable; (iii) 12 stimulation, sustained decrease hospitalizations.