Characterization of pharyngeal peristaltic pressure variability during volitional swallowing in healthy individuals

• DOI: 10.1111/nmo.13119
• Publication Date: 2017-06-21T04:06:51Z
• Authors: G. Balasubramanian; T. Sharma; M. Kern; L. Mei; P. Sanvanson; R. Shaker
• Keywords: Peristalsis

Abstract Background Recent technological advances incorporated in high resolution manometry have justifiably heightened interest manometric evaluation of the pharynx. Despite this interest, from both physiologic and clinical perspective there remain a number unanswered questions regarding magnitude variability pharyngeal pressure phenomena. Therefore, aim present study was to characterize healthy individuals inter‐subject recording‐site specific peristaltic Methods We studied 32 subjects (age: 21‐83 years,20 under 35 years) during dry,5 10 mL water swallows ×3. Pharyngeal pressures were recorded using ( HR ) system catheter assembly with 36 circumferential sensors spaced at 1 cm intervals positioned trans‐nasally traverse pharynx, UES proximal esophagus. Key Results Both site‐specific data contractile integral (PhCI) showed wide dispersion ranging between values 50 mm Hg over 300 100‐600 Hg/cm/s,respectively. There also range for standard deviations coefficient variation all sites P =.001). The PhCI ranged 0.02 0.25 representing 2‐25 percent mean among Position, age volume swallowed fluid did not influence variability. Conclusions Deglutitive peristalsis generates significant degree site‐related This is influenced by age, position fluid.