Comparison between small bowel manometric patterns and full‐thickness biopsy histopathology in severe intestinal dysmotility

• DOI: 10.1111/nmo.13219
• Publication Date: 2017-09-22T08:08:40Z
• Authors: C. Malagelada; T. B. Karunaratne; A. Accarino; R. F. Cogliandro; S. Landolfi; A. Gori; E. Boschetti; J. R. Malagelada; V. Stanghellini; F. Azpiroz; R. De Giorgio
• Keywords: Histopathology; Intestinal pseudo-obstruction

Abstract Background Intestinal manometry is the current standard for direct evaluation of small bowel dysmotility. Patients with abnormal motility can either be diagnosed pseudo‐obstruction when there are radiological findings mimicking mechanical intestinal obstruction or enteric dysmotility these absent. The aim present study was to prospectively compare manometric abnormalities histopathological in full‐thickness biopsies patients severe disorders. Methods We investigated 38 and a subsequent biopsy. Manometric recordings were read by 4 investigators diagnostic consensus obtained 35 patients. Histopathological analysis, including specific immunohistochemical techniques performed compared readings. Key Results had 73% cases. However, patterns did not match neuromuscular abnormalities. Among neuropathic pattern histopathology, only 23% an neuropathy, whereas 62% inflammation, 15% myopathy. On other hand, myopathic all however, none them signs Conclusion & Inferences Small detected often associated biopsies. no correlation between findings.