Comparison between small bowel manometric patterns and full‐thickness biopsy histopathology in severe intestinal dysmotility

• DOI: 10.1111/nmo.13219
• Publication Date: 2017-09-22T08:08:40Z
• Authors: C. Malagelada; T. B. Karunaratne; A. Accarino; R. F. Cogliandro; S. Landolfi; A. Gori; E. Boschetti; J. R. Malagelada; V. Stanghellini; F. Azpiroz; R. De Giorgio
• Keywords: Adult; Male; 0301 basic medicine; Adolescent; Manometry; full-thickness intestinal resection; functional bowel disorders; histopathology; intestinal manometry; motility; small intestine; Biopsy; Reproducibility of Results; Middle Aged; 3. Good health; Young Adult; 03 medical and health sciences; Intestine, Small; Humans; Female; Gastrointestinal Motility; Intestinal Obstruction; Aged

AbstractBackgroundIntestinal manometry is the current standard for direct evaluation of small bowel dysmotility. Patients with abnormal motility can either be diagnosed of pseudo‐obstruction when there are radiological findings mimicking mechanical intestinal obstruction or of enteric dysmotility when these findings are absent. The aim of the present study was to prospectively compare small bowel manometric abnormalities with histopathological findings in intestinal full‐thickness biopsies in patients with severe dysmotility disorders.MethodsWe investigated 38 patients with intestinal manometry and a subsequent full‐thickness intestinal biopsy. Manometric recordings were read by 4 investigators and a diagnostic consensus was obtained in 35 patients. Histopathological analysis, including specific immunohistochemical techniques of small bowel biopsies was performed and compared to manometric readings.Key ResultsPatients with abnormal intestinal manometry had abnormal histopathological findings in 73% of cases. However, manometric patterns did not match with the specific neuromuscular abnormalities. Among patients with a neuropathic manometry pattern and abnormal histopathology, only 23% had an enteric neuropathy, whereas 62% had neuromuscular inflammation, and 15% an enteric myopathy. On the other hand, patients with a myopathic manometry pattern all had abnormal histopathology, however, none of them with signs of enteric myopathy.Conclusion & InferencesSmall bowel dysmotility detected by intestinal manometry is often associated with abnormal neuromuscular findings in full‐thickness biopsies. However, there is no correlation between the specific manometric patterns and the histopathological findings.