Brain processing of rectal sensation in adolescents with functional defecation disorders and healthy controls

• DOI: 10.1111/nmo.13228
• Publication Date: 2017-10-04T09:59:40Z
• Authors: S. M. Mugie; I. J. N. Koppen; M. M. van den Berg; P. F. C. Groot; L. Reneman; M. B. de Ruiter; M. A. Benninga
• Keywords: Dorsolateral prefrontal cortex; Postcentral gyrus; Barostat

Abstract Background Decreased sensation of urge to defecate is often reported by children with functional constipation ( FC ) and nonretentive fecal incontinence FNRFI ). The aim this cross‐sectional study was evaluate cerebral activity in response rectal distension adolescents compared healthy controls HC s). Methods We included 15 , 10 young adult s. Rectal barostat performed prior magnetic resonance imaging fMRI determine individual pressure thresholds for sensation. Subjects received 2 sessions 5 × 30 seconds stimulation during the acquisition blood oxygenation level‐dependent . Functional signal differences were analyzed using SPM 8 Matlab. Key Results patients had higher urgency than s P < .001). During distension, showed activation anterior cingulate cortex, dorsolateral prefrontal inferior parietal lobule, putamen. No activations observed patients. deactivation hippocampus, parahippocampal gyrus, fusiform gyrus FFG ), lingual posterior precentral gyrus. In s, deactivated areas detected amygdala, insula, thalamus, precuneus, primary somatosensory cortex. contrast, no regions significant Conclusions & Inferences Children differ from respect patterns distension. seem resemble when it comes brain processing