Gastroparesis syndromes: Response to electrical stimulation

• DOI: 10.1111/nmo.13534
• Publication Date: 2019-02-01T01:11:15Z
• Authors: Thomas L. Abell; Archana Kedar; Abigail Stocker; Karen Beatty; Lindsay McElmurray; Michael Hughes; Hani Rashed; William Kennedy; Gwen Wendelschafe...; Xiu Yang; Mostafa Fraig; Endashaw Omer; Ed Miller; Michael Griswold; Christina Pinkston
• Keywords: Gastroparesis; Pathophysiology

Factors underlying gastroparesis are not well defined, nor is the mechanism of action gastric electrical stimulation (GES). We hypothesized that GES acts via several mechanisms related to disordered pathophysiology.We studied 43 consecutive eligible patients with gastroparetic symptoms, previously evaluated by two methods in each five core areas: inflammatory, autonomic, enteric, electrophysiologic, and hormonal; also categorized GI metabolic status, illness quantification, physiology. then 41 who underwent temporary for 5-7 days. Thirty-six those were implanted 30 followed up at 6 months after permanent GES.In previous but separately reported work, had similar symptoms regardless baseline emptying or diabetic/idiopathic status all demonstrated abnormalities areas studied. After GES, showed early late effects changes noted multiple areas, improvement status.Patients have abnormalities, including systemic inflammation hormonal status. affects many these abnormalities. conclude improves physiology (a) an sustained anti-emetic effect; (b) durable prokinetic effect delayed patients; (c) anti-arrhythmic continues over time; (d) a autonomic (e) (f) anti-inflammatory persists; (g) health-related quality life. This study registered Clinicaltrials.gov under # NCT03178370 (https://clinicaltrials.gov/ct2/show/NCT03178370).