Nausea exacerbates symptom burden, quality of life, and functioning in adolescents with functional abdominal pain disorders

• DOI: 10.1111/nmo.13595
• Publication Date: 2019-04-08T05:54:35Z
• Authors: Katja Kovacic; Prasanna K. Kapav...; Manu R. Sood; B U. K. Li; Melodee Nugent; Pippa Simpson; Adrian Miranda
• Keywords: Male; Adolescent; Gastrointestinal Diseases; Nausea; Abdominal Pain; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Chronic Disease; Quality of Life; Humans; Female

Nausea frequently co-exists with functional abdominal pain disorders (FAPDs) and may be linked to a higher disease burden. This study aimed prospectively compare multisystem symptoms, quality of life, functioning in FAPDs without nausea.Adolescents ages 11-18 years fulfilling Rome III criteria for FAPD were grouped by the presence or absence chronic nausea. Subjects completed validated instruments assessing nausea (Nausea Profile Questionnaire = NPQ), life (Patient-Reported Outcome Measurement Information System), (Functional Disability Inventory), anxiety (State-Trait Anxiety Inventory Children). Group comparisons performed instruments, school absences, clinical diagnoses.A total 112 subjects included; 71% reported Patients compared No had NPQ scores (P ≤ 0.001), worse 0.004), greater disability 0.02). State trait similar 0.57, P 0.25). A score correlated poorer more disability, anxiety. Specific comorbidities common vs group: dizziness (81% 41%; concentrating difficulties (68% 27%; fatigue (58% 20%; 0.01), sleep disturbances (73% 48%; The group absences 0.001) commonly met dyspepsia 0.034).Nausea co-existing is associated extra-intestinal symptom burden, impaired children. Assessing targeting therapeutically essential improve outcomes FAPDs.