Prokinetics‐safety and efficacy: The European Society of Neurogastroenterology and Motility/The American Neurogastroenterology and Motility Society expert review

• DOI: 10.1111/nmo.14774
• Publication Date: 2024-03-11T04:30:35Z
• Authors: Serhat Bor; İsmail H. Kalkan; Edoardo Savarino; Satish Rao; Jan Tack; Jay Pasricha; David Cangemi; Jolien Schol; Tennekoon Karunar...; Matteo Ghisa; Nitin K. Ahuja; Brian Lacy
• Keywords: Tolerability; Prokinetic agent

Abstract Background Prokinetics are a class of pharmacological drugs designed to improve gastrointestinal (GI) motility, either regionally or across the whole gut. Each drug has its merits and drawbacks, based on current evidence as high‐quality studies limited, we have no clear recommendation one other. However, there remains large unmet need for both selective and/or globally acting prokinetic that work primarily intraluminally safe without systemic side effects. Purpose Here, describe strengths weaknesses six classes drugs, including their pharmacokinetic properties, efficacy, safety tolerability potential indications.