Electroacupuncture at Zusanli (ST36) Alleviate Intestinal Ischemia‐Reperfusion Injury by Regulating the Cholinergic‐miRNA 124 Pathway

• DOI: 10.1111/nmo.14971
• Publication Date: 2024-12-02T05:15:27Z
• Authors: YanXia Geng; Hai Lv; Yu Liu; DingDing Guo; JingJing Zheng; YingXin Li; Hua Jiang; Dong Chen
• Keywords: Zusanli

ABSTRACT Objective Intestinal ischemia‐reperfusion injury (IIRI) is common in a variety of critical diseases and acute stress, acupuncture promising treatment for IIRI. The aim this study to explore the mechanism electroacupuncture (EA) at Zusanli (ST36) improving IIRI from perspective cholinergic anti‐inflammatory pathway (CAP) miRNA 124. Methods Seven groups mice were performed: Control group, I/R group (IIRI model), EA (I/R + EA), mimic 124 mimic), inhibitor inhibitor), PNU α7nAChR agonist), MLA EA+ antagonist). expression intestinal macrophages, α7nAChR, 124, related molecules, including p‐STAT3 IL‐6, as well histological damage (Chiu's score) mucosal permeability (serum FD4 concentration), detected. Results serum concentrations significantly lower compared ( p < 0.05). EA, mimic, was higher than that 0.05), while levels IL‐6 reduced Conversely, groups, increased Conclusion may induce miRNA124 through on which be key neuro‐immune target