Liver stiffness correlates with serum osteopontin and TAZ expression in human liver cirrhosis

• DOI: 10.1111/nyas.14259
• Publication Date: 2019-11-07T11:00:10Z
• Authors: Zohreh Khajehahmadi; Sina Mohagheghi; Saman Nikeghbalian; Bita Geramizadeh; Iraj Khodadadi; Jamshid Karimi; Heidar Tavilani
• Keywords: Osteopontin; Matricellular protein

Abstract The pivotal role of the extracellular matrix (ECM) as both a cause and consequence liver fibrosis is striking. However, mechanotransducer molecules profibrogenic factors induced by stiffness are still unclear. current study aimed to investigate its correlation with expression transcriptional coactivator PDZ‐binding motif (TAZ) serum osteopontin (OPN) in human cirrhosis. In this case−control study, tissue was determined using atomic force microscopy cirrhotic livers ( n = 38) different etiologies controls 10). Immunohistochemical qRT‐PCR analyses were performed analyze TAZ expression. Besides, western blotting ELISA assess Indian hedgehog OPN levels, respectively. Liver stiffness, expression, hepatic gene protein levels significantly increased patients cirrhosis compared control groups (all P < 0.001), specifically autoimmune‐ alcohol‐related patients, associated nuclear OPN. between mechanical property, potential mechanotransducer, matricellular factor suggests possible effects features ECM on aforementioned markers, which predominant