PRDM1 expression on the epithelial component but not on ectopic lymphoid tissues of Warthin tumour

• DOI: 10.1111/odi.12294
• Publication Date: 2014-10-03T15:56:37Z
• Authors: Y Wang; J Zhou; Y Zhang; L Wang; Y Liu; L Fan; J Zhu; X Xu; G Huang; X Li; W Xun
• Keywords: Adult; Aged, 80 and over; Male; Lymphoid Tissue; Epithelial Cells; Middle Aged; Adenolymphoma; Germinal Center; Immunohistochemistry; Parotid Neoplasms; 3. Good health; Repressor Proteins; 03 medical and health sciences; 0302 clinical medicine; Humans; Parotid Gland; Female; Positive Regulatory Domain I-Binding Factor 1; Aged

ObjectiveTo determine the role of PRDM1, a key molecule for modulating the immune cells, in Warthin tumour (WT) pathogenesis.Subjects and methodsForty paraffin‐embedded parotid tissues of patients (mean age: 62.08 ± 11.90) with WT were retrieved from the pathology archives of Qindu Hospital from January 2012 to December 2012. The PRDM1 expression was investigated in a cohort of WT by immunohistochemistry.ResultsPRDM1 was expressed only on the epithelial component but not on ectopic lymphoid tissue of the tumour. Statistically, PRDM1 expression rates between WT glandular epithelial cells (40/40 cases) and the tumour‐adjacent tissues (0/9 cases), and WT germinal centres (0/34 cases) and tonsil tissues (10/10 cases) were significantly different (P < 0.001), respectively.ConclusionsThe PRDM1 expression appeared to play an essential role in WT pathogenesis. A better understanding of it might give options for revealing possible novel management strategies.