Nanoparticles for controlled delivery and sustained release of chlorhexidine in the oral environment

• DOI: 10.1111/odi.12328
• Publication Date: 2015-02-20T06:26:01Z
• Authors: S Garner; ME Barbour
• Keywords: 03 medical and health sciences; Drug Delivery Systems; 0302 clinical medicine; Delayed-Action Preparations; Chlorhexidine; Anti-Infective Agents, Local; Microscopy, Electron, Scanning; Administration, Oral; Nanoparticles; Phosphates; 12. Responsible consumption; 3. Good health

Objectives Chlorhexidine ( CHX ) is in widespread use as a topical antimicrobial agent. Within the field of oral medicine, it used prevention ventilator‐associated pneumonia well treatment candidosis and microbial‐associated lichenoid reactions. The objective this study was to develop strategy for controlled, sustained delivery using nanoparticle technology. Methods applied hydroxyapatite, selected tooth analogue, conventional digluconate solutions aqueous suspensions hexametaphosphate nanoparticles with total concentrations 1, 2.2 5 mM. Soluble release from treated hydroxyapatite monitored over period 7 days. Results A repeated‐measures ANOVA post hoc LSD test indicated that 2–3× greater, longer, when delivered than solution mM P = 0.020 0.013, respectively), but there no statistically significant difference at 1 0.172). Conclusions increased both local dose duration soluble surfaces. This may provide means deliver less frequent interventions.