Nanoparticles for controlled delivery and sustained release of chlorhexidine in the oral environment
03 medical and health sciences
Drug Delivery Systems
0302 clinical medicine
Delayed-Action Preparations
Chlorhexidine
Anti-Infective Agents, Local
Microscopy, Electron, Scanning
Administration, Oral
Nanoparticles
Phosphates
12. Responsible consumption
3. Good health
DOI:
10.1111/odi.12328
Publication Date:
2015-02-20T06:26:01Z
AUTHORS (2)
ABSTRACT
Objectives Chlorhexidine ( CHX ) is in widespread use as a topical antimicrobial agent. Within the field of oral medicine, it used prevention ventilator‐associated pneumonia well treatment candidosis and microbial‐associated lichenoid reactions. The objective this study was to develop strategy for controlled, sustained delivery using nanoparticle technology. Methods applied hydroxyapatite, selected tooth analogue, conventional digluconate solutions aqueous suspensions hexametaphosphate nanoparticles with total concentrations 1, 2.2 5 mM. Soluble release from treated hydroxyapatite monitored over period 7 days. Results A repeated‐measures ANOVA post hoc LSD test indicated that 2–3× greater, longer, when delivered than solution mM P = 0.020 0.013, respectively), but there no statistically significant difference at 1 0.172). Conclusions increased both local dose duration soluble surfaces. This may provide means deliver less frequent interventions.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (26)
CITATIONS (18)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....