Nanoparticles for controlled delivery and sustained release of chlorhexidine in the oral environment

03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Delayed-Action Preparations Chlorhexidine Anti-Infective Agents, Local Microscopy, Electron, Scanning Administration, Oral Nanoparticles Phosphates 12. Responsible consumption 3. Good health
DOI: 10.1111/odi.12328 Publication Date: 2015-02-20T06:26:01Z
ABSTRACT
Objectives Chlorhexidine ( CHX ) is in widespread use as a topical antimicrobial agent. Within the field of oral medicine, it used prevention ventilator‐associated pneumonia well treatment candidosis and microbial‐associated lichenoid reactions. The objective this study was to develop strategy for controlled, sustained delivery using nanoparticle technology. Methods applied hydroxyapatite, selected tooth analogue, conventional digluconate solutions aqueous suspensions hexametaphosphate nanoparticles with total concentrations 1, 2.2 5 mM. Soluble release from treated hydroxyapatite monitored over period 7 days. Results A repeated‐measures ANOVA post hoc LSD test indicated that 2–3× greater, longer, when delivered than solution mM P = 0.020 0.013, respectively), but there no statistically significant difference at 1 0.172). Conclusions increased both local dose duration soluble surfaces. This may provide means deliver less frequent interventions.
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