Preventive dental management of osteonecrosis of the jaws related to zoledronic acid treatment

• DOI: 10.1111/odi.12842
• Publication Date: 2018-02-07T14:53:02Z
• Authors: JA Coello‐Suanzes; V Rollon‐Ugalde; A Castaño‐Seiquer; E Lledo‐Villar; J Herce‐Lopez; P Infante‐Cossio; A Rollon‐Mayordomo
• Keywords: Zoledronic Acid; Log-rank test

Objective To evaluate the effect of preventive dental management on reducing incidence and delaying onset bisphosphonate‐related osteonecrosis jaw ( BRONJ ) in patients treated with intravenous zoledronic acid ZA ). Materials Methods This single‐center clinical study included 255 cancer monitored over a 6‐year period. Patients received treatment prior to (group A) or after B) initiation therapy. Dental treatments performed, proportion IP ), rate IR both groups were analyzed using significance tests. was estimated Kaplan–Meier estimator log‐rank test. Independent risk factors develop evaluated Cox regression analysis models. Results Thirty‐seven suffered from = 14.5%), 7.3% group A 36.5% B p .000). The 0.007 patients/month 0.004 A. ‐free survival at 3 years 97% 66% B. Survival curves significant .056) according Multivariate models showed that extractions .000) significant. Conclusions occurred significantly who underwent did not accomplish program.