High referral accuracy for oral cancers and oral potentially malignant disorders using telemedicine

• DOI: 10.1111/odi.13892
• Publication Date: 2021-04-29T17:04:59Z
• Authors: Nabihah Haron; Senthilmani Rajen...; Thomas George Kal...; Rosnah Binti Zain; Anand Ramanathan; Mannil Thomas Abr...; Shin Hin Lau; Lai Choo Cheng; Sherrie Mei Yee C...; Farah Aliya Moham...; Zuraiza Mohamad Z...; Siew Wui Chan; Yet Ching Goh; Daniel Lim; Juliana Khairi; Marzuki Zainal Ab...; Zainal Ariff Abdu...; Chee Sun Liew; Siew Chinn Fong; Yi‐Hsin Yang; Siti Mazlipah Ismail; Sok Ching Cheong
• Keywords: Adult; RK Dentistry; 610; R Medicine (General); Sensitivity and Specificity; Telemedicine; 3. Good health; 03 medical and health sciences; Oral surgery; 0302 clinical medicine; 617; Humans; Mouth Neoplasms; Prospective Studies; Referral and Consultation

AbstractObjectiveTo evaluate the accuracy of MeMoSA®, a mobile phone application to review images of oral lesions in identifying oral cancers and oral potentially malignant disorders requiring referral.Subjects and MethodsA prospective study of 355 participants, including 280 with oral lesions/variants was conducted. Adults aged ≥18 treated at tertiary referral centres were included. Images of the oral cavity were taken using MeMoSA®. The identification of the presence of lesion/variant and referral decision made using MeMoSA® were compared to clinical oral examination, using kappa statistics for intra‐rater agreement. Sensitivity, specificity, concordance and F1 score were computed. Images were reviewed by an off‐site specialist and inter‐rater agreement was evaluated. Images from sequential clinical visits were compared to evaluate observable changes in the lesions.ResultsKappa values comparing MeMoSA® with clinical oral examination in detecting a lesion and referral decision was 0.604 and 0.892, respectively. Sensitivity and specificity for referral decision were 94.0% and 95.5%. Concordance and F1 score were 94.9% and 93.3%, respectively. Inter‐rater agreement for a referral decision was 0.825. Progression or regression of lesions were systematically documented using MeMoSA®.ConclusionReferral decisions made through MeMoSA® is highly comparable to clinical examination demonstrating it is a reliable telemedicine tool to facilitate the identification of high‐risk lesions for early management.