Localization and characterization of human papillomavirus‐16 in oral squamous cell carcinoma

• DOI: 10.1111/odi.13920
• Publication Date: 2021-05-22T16:49:53Z
• Authors: Wafaa Saleh; Seunghee Cha; Abdulaziz Banasser; Sarah G. Fitzpatrick; Indraneel Bhattac...; Jilan M. Youssef; Mohamed M. Anees; Islam A. Elzahaby; Joseph Katz
• Keywords: Human papillomavirus 16; Squamous Cell Carcinoma of Head and Neck; Papillomavirus Infections; Human Papillomavirus Viruses; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Head and Neck Neoplasms; Carcinoma, Squamous Cell; Humans; Mouth Neoplasms; Papillomaviridae; Cyclin-Dependent Kinase Inhibitor p16

The role of Human papillomavirus (HPV) in the oral squamous cell carcinoma (OSCC) has not been completely elucidated. purpose present study was to investigate prevalence and localization HPV-16 virus OSCC correlate positivity p16INK4A expression with clinical pathological features OSCC.The archives Oral Pathology at University Florida, College Dentistry were accessed for demographic, clinical, histopathological data, slides 114 patients. evaluated by immunohistochemistry (IHC) E6/E7mRNA situ hybridization (ISH).Out consecutive OSCC, 16 samples (14%) showed IHC 14 (12%) positive ISH Positivity a significant correlation patients' age, alcohol consumption, degree OSSC differentiation. hard palate highest mRNA (38%, 36% respectively).HPV-16 is factor carcinogenesis. We recommend using as surrogate marker HPV detection which can be complemented RNA identification subtypes.