A proof of concept pilot trial of probiotics in symptomatic oral lichen planus (CABRIO)

• DOI: 10.1111/odi.14014
• Publication Date: 2021-08-31T22:34:50Z
• Authors: Erni Marlina; Richard N. Goodman; Valeria Mercadante; Martina Shephard; Roddy McMillan; Tim Hodgson; Rachel Leeson; Stephen Porter; Julie A. Barber; Stefano Fedele; Andrew M. Smith
• Keywords: Oral Lichen Planus

To preliminary evaluate the clinical effects of probiotics in individuals with symptomatic oral lichen planus and possible mechanisms action.A group 30 were recruited a randomised double-blind parallel controlled (1:1) proof-of-concept pilot trial probiotic VSL#3 vs placebo. Efficacy outcomes included changes pain numeric rating scale, disease severity score chronic mucosal questionnaire. Adverse effects, home diary withdrawals assessed as feasibility outcomes. Mechanistic salivary serum levels CXCL10 IFN-γ microbial composition.The was safe well tolerated. We observed no statistically significant change pain, activity, quality life, serum/salivary or composition respect to Salivary demonstrate trend for reduced level active (p = 0.082) after days consumption.The present study provides some weak not convincing indication biological painful planus. Further research this field is needed, current providing useful information design future trials.