A proof of concept pilot trial of probiotics in symptomatic oral lichen planus (CABRIO)
Oral Lichen Planus
DOI:
10.1111/odi.14014
Publication Date:
2021-08-31T22:34:50Z
AUTHORS (11)
ABSTRACT
To preliminary evaluate the clinical effects of probiotics in individuals with symptomatic oral lichen planus and possible mechanisms action.A group 30 were recruited a randomised double-blind parallel controlled (1:1) proof-of-concept pilot trial probiotic VSL#3 vs placebo. Efficacy outcomes included changes pain numeric rating scale, disease severity score chronic mucosal questionnaire. Adverse effects, home diary withdrawals assessed as feasibility outcomes. Mechanistic salivary serum levels CXCL10 IFN-γ microbial composition.The was safe well tolerated. We observed no statistically significant change pain, activity, quality life, serum/salivary or composition respect to Salivary demonstrate trend for reduced level active (p = 0.082) after days consumption.The present study provides some weak not convincing indication biological painful planus. Further research this field is needed, current providing useful information design future trials.
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