Family history of cancer is associated with poorer prognosis in oral squamous cell carcinoma

• DOI: 10.1111/odi.14253
• Publication Date: 2022-05-17T09:14:25Z
• Authors: Ranran Xiao; Jinghan Wu; Brent B. Ward; Huan Liu; Bo Li; Chong Wang; Qiaoshi Xu; Zhengxue Han; Zhien Feng
• Keywords: 0301 basic medicine; Squamous Cell Carcinoma of Head and Neck; 610; Prognosis; family history of cancer; prospective database; 3. Good health; oral squamous cell carcinoma; 03 medical and health sciences; Head and Neck Neoplasms; Dentistry; Health Sciences; Carcinoma, Squamous Cell; Humans; Mouth Neoplasms; prognosis; Retrospective Studies

AbstractObjectiveThe purpose of this study was to investigate the prognostic value of the family history of cancer (FHC) in predicting survival and clinicopathological features in oral squamous cell carcinoma (OSCC) patients.Materials and MethodsThis single‐institution study utilized data from 610 patients undergoing surgery from 2014 to 2020 that was prospectively collected and cataloged for research purposes. All patients underwent standard surgery with/without radiotherapy or chemoradiotherapy. We statistically evaluated whether FHC was associated with changes in disease‐free survival (DFS) and disease‐specific survival (DSS).ResultsAmong 610 patients, 141 (23.1%) reported a family history of cancer. The distribution of clinicopathological characteristics was balanced between FHC‐positive and FHC‐negative OSCC patients. FHC‐positive patients had decreased DFS (p = 0.005) and DSS (p = 0.018) compared to FHC‐negative patients.ConclusionsFHC‐positive OSCC patients have a poorer prognosis. FHC positivity is an independent predictor of negative outcomes based on DFS and DSS. FHC should be a consideration in screening, evaluating, counseling, and treating OSCC patients.