Effects of Fluid Gelatin for Lumbar Spinal Stenosis Undergoing Lumbar Endoscopic Bilateral Decompression: A Prospective, Randomized Controlled Trial

• DOI: 10.1111/os.14373
• Publication Date: 2025-03-11T16:02:34Z
• Authors: Hao Yan; Mingdong Yu; Huaibin Wang; Rongsheng Dou; Xiaoyan Xia; Ruzhan Yao; Weiqiang Liu; Jesse Li‐Ling

ABSTRACT Objectives In patients with lumbar spinal stenosis (LSS), prolonged compression of the epidural venous plexus heightens risk bleeding and hematoma during minimally invasive surgery. While absorbable fluid gelatin, an animal protein–based hemostatic agent, is available, its effectiveness in endoscopic unilateral laminotomy bilateral decompression (LE‐ULBD) remains debated. Our research aims to conduct a prospective randomized controlled trial investigate safety this material undergoing LE‐ULBD for LSS. Methods From October 2023 July 2024, total 90 LSS who underwent were enrolled study. The randomly divided into two groups: gelatin group (45 cases, using gelatin) null‐fluid not gelatin). Primary outcomes included success rate achieving hemostasis within 3 min symptomatic postoperative (SPEH). Secondary encompassed surgical time, intraoperative blood loss, perioperative length stay, complications. Independent sample t tests used compare continuous data. Chi‐squared Fisher's exact probability analyze categorical Results ( p < 0.05) was significantly higher compared that group, loss time notably lower group. However, there no statistically significant differences between groups regarding complications, such as SPEH, allergy, thrombus. Conclusion surgery, can achieve rapid hemostasis, shorten reduce without causing Therefore, conventional use surgery effective safe strategy.