Ventricular tachycardia incidence and erythrocyte membranes β‐adrenoreactivity in patients with implanted cardioverter‐defibrillator

• DOI: 10.1111/pace.14479
• Publication Date: 2022-03-14T14:54:55Z
• Authors: Tariel A. Atabekov; Roman E. Batalov; Tatiana Yu. Rebrova; Sergey N. Krivolapov; Elvira F. Muslimova; Mikhail S. Khlynin; Sergey A. Afanasiev; Sergey V. Popov
• Keywords: Fibrillation

In patients with high risk of ventricular tachycardia (VT) the proven beneficial therapy is implantable cardioverter defibrillator (ICD). It has been shown that coronary artery disease (CAD) and VT development are accompanied by a persistent change sympathoadrenal system activity. This leads to decrease in total density erythrocyte membrane β-adrenergic receptors. The purpose this study was identify relationship membranes β-adrenoreactivity (EMA) CAD ICD.Sixty-three (male - 53, age 66.6 ± 9.2 years) ICD were included study. EMA studied using method for assessing osmoresistance increase as result receptors blockade selective blocker. fibrillation (VF) events recorded evaluated.The 1st group consist 23 VT/VF during 27.0 [14.0; 53.0] months follow-up period. indicator 41.54% [27.15; 51.26]. 2nd 40 without same significantly higher 55.42% [35.67; 62.33] (p = .04). ROC-analysis (AUC 0.657; Sen 78.26; Spe 55.00; p .031) binary logistic regression (OR 0.9679; 95% CI: 0.9384-0.9983; .038) showed 51.26% or lower independent predictor events.In episodes.