Alterations in the gut microbiotas of children with food sensitization in early life

• DOI: 10.1111/pai.12522
• Publication Date: 2015-12-12T21:46:03Z
• Authors: Chien‐Chang Chen; Kun‐Jei Chen; Man‐Shan Kong; Hung‐Ju Chang; Jing‐Long Huang
• Keywords: Ruminococcus; Veillonella; Prevotella; Akkermansia; Fusobacteria; Roseburia; Lachnospiraceae

We hypothesized that food sensitization (FS) in children could be linked to specific gut microbiota. The aim of our study is quantify and evaluate differences microbiota composition between with FS healthy controls.A case-control 23 22 was performed. Individual microbial diversity were analyzed via parallel barcoded 454 pyrosequencing targeting the 16S rRNA gene hypervariable V3-V5 regions.The exhibited lower both total (p = 0.01) bacterial phylum Bacteroidetes 0.02). In these children, number bacteria significantly decreased Firmicutes increased compared children. At genus level, we observed significant increases numbers Sphingomonas, Sutterella, Bifidobacterium, Collinsella, Clostridium sensu stricto, IV, Enterococcus, Lactobacillus, Roseburia, Faecalibacterium, Ruminococcus, Subdoligranulum, Akkermansia group. also found decreases Bacteroides, Parabacteroides, Prevotella, Alistipes, Streptococcus, Veillonella this Furthermore, linear discriminant analysis (LDA) coupled effect size measurements revealed most differentially abundant taxa (increased abundances IV Subdoligranulum Bacteroides Veillonella), which used identify FS.Our results showed associated compositional changes These findings useful for developing strategies control development or atopy by modifying