Molecular sensitization patterns and influence of molecular diagnosis in immunotherapy prescription in children sensitized to both grass and olive pollen

• DOI: 10.1111/pai.12866
• Publication Date: 2018-01-25T15:56:53Z
• Authors: Ana Martínez‐Caña...; Javier Torres‐Bor...; Ana Belén Molina ...; Jose Luis Corzo; Blanca Esther García; Ramón Rodríguez P...; Carmen Moreno Agu...; Ignacio Dávila
• Keywords: Male; *double sensitization; grass; Adolescent; *pediatric population; specific IgE; seasonal allergic rhinitis; *specific IgE; *seasonal allergic rhinitis; Cross Reactions; Poaceae; olive; 03 medical and health sciences; 0302 clinical medicine; Olea; molecular diagnosis; Humans; Child; double sensitization; Infant; Rhinitis, Allergic, Seasonal; *olive; Allergens; Antigens, Plant; Immunoglobulin E; 3. Good health; Cross-Sectional Studies; Desensitization, Immunologic; Spain; Child, Preschool; *grass; *molecular diagnosis; Pollen; Female; immunotherapy; *immunotherapy; pediatric population; Biomarkers

Abstract Background The overlapping grass and olive pollen seasons in Spain the phenomenon of cross‐reactivity can make it difficult to determine true causative agent seasonal allergic rhinitis when only skin prick tests with whole extracts are used. aim GRAMOLE study was sensitization patterns major allergens detected using specific recombinant IgE explore how this knowledge affected physicians’ choice allergen‐specific immunotherapy. Methods Epidemiological, observational, multicenter, cross‐sectional study. Results from children under 18 years age diagnosed by positive were analyzed. Specific Phl p 1+5, Ole e 1, 7+12 determined. Investigators specified optimal composition allergen immunotherapy before after knowing results molecular diagnosis. A total 281 patients a mean 13.4 included. Double both found vitro 76% for an cutoff point 0.35 kU/L. When diagnosis known, specialists changed prescribed 52.87% cases. Conclusions is common also occurs pediatric population. Molecular may help improve selection polysensitized patients.