The inflammatory potential of diet impacts the association between air pollution and childhood asthma
Male
Allergy
Immunology
610
CHILDREN
PM2.5
Pediatrics
1117 Public Health and Health Services
03 medical and health sciences
0302 clinical medicine
Air Pollution
Surveys and Questionnaires
11. Sustainability
QUALITY
Humans
OXIDATIVE STRESS
Child
ANTIOXIDANT SUPPLEMENTATION
Inflammation
Air Pollutants
Science & Technology
Schools
Portugal
Health sciences, Medical and Health sciences
Ciências médicas e da saúde
school exposure
Environmental Exposure
asthma
Asthma
Diet
3. Good health
indoor pollution
ENERGY-INTAKE
1107 Immunology
13. Climate action
Air Pollution, Indoor
Medical and Health sciences
dietary inflammatory index
1114 Paediatrics and Reproductive Medicine
Female
Particulate Matter
Ciências da Saúde, Ciências médicas e da saúde
Life Sciences & Biomedicine
DOI:
10.1111/pai.13185
Publication Date:
2019-12-09T15:56:22Z
AUTHORS (11)
ABSTRACT
AbstractBackgroundInhalation of fine particulate matter (PM) can cause systematic inflammation and oxidative stress, which may further aggravate the development and progression of asthma. Although nutritional intake of fatty acids and antioxidants may attenuate some effects of fine PM, the role of the inflammatory potential of diet has not been addressed. Therefore, we aimed to investigate possible modulatory effects of dietary inflammatory potential on the association between indoor air pollution and childhood asthma–related outcomes.MethodsIn a sample of 501 children (48.1% females, aged 7‐12 years) from 20 public schools located in Porto, Portugal, we evaluated airway reversibility, exhaled nitric oxide levels, atopy, and current respiratory symptoms. Dietary inflammatory index was calculated based on information collected through a reported 24‐hour recall questionnaire, and participants were categorized as having an anti‐inflammatory or pro‐inflammatory diet. Concentrations of indoor PM2.5 and PM10 were measured to assess indoor air quality. Generalized linear mixed models were used to investigate the proportion of effects explained by the exposure to PM2.5 and PM10.ResultsAfter adjustment, the exposure effect of PM2.5 and PM10 levels on children with asthma was higher for those having a pro‐inflammatory diet (OR = 1.44, 95% CI: 1.01‐2.21; and OR = 1.29, 95% CI: 1.03‐1.68, respectively) compared to those having an anti‐inflammatory diet.ConclusionThese findings suggest that the quality of diet might affect the association between indoor pollution and asthma in children, highlighting the relevance of children's diet as a potential protective factor to pollutant exposure in childhood asthma.
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CITATIONS (31)
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