Airway bacterial carriage and childhood respiratory health: A population‐based prospective cohort study

• DOI: 10.1111/pai.13310
• Publication Date: 2020-06-11T01:35:44Z
• Authors: Evelien R. van Meel; Vincent W. V. Jaddoe; Kirsten I. M. Looman; Johan C. de Jongste; Henriëtte A. Moll; Liesbeth Duijts
• Keywords: Carriage; Respiratory tract

Abstract Background Airway bacterial carriage might play a role in respiratory disease. We hypothesize that nasal with Staphylococcus aureus or nasopharyngeal Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae predisposes individuals to adverse health. Objective To examine the association of early‐life airway tract infections vice versa, wheezing, lung function, asthma later childhood. Methods collected upper swabs for culturing S aureus, H M influenzae at six timepoints between ages 6 weeks years among 945 children participating population‐based prospective cohort study. Information on wheezing until age years, 10 was obtained by questionnaires. Lung function measured spirometry. tested possible bidirectional associations cross‐lagged models, repeatedly generalized estimating equations models regression models. Results Cross‐lagged modeling showed not consistently associated lower versa. Nasopharyngeal any bacteria infancy an increased risk (OR [95% CI]: 1.66 [1.31, 2.10]). school‐age asthma. Conclusion is but infections, asthma, function.