Prevalence of childhood wheeze and modified DNA methylation at 7 years of age according to maternal folate levels during pregnancy in the Hokkaido Study

• DOI: 10.1111/pai.13425
• Publication Date: 2020-12-04T07:34:51Z
• Authors: Chihiro Miyashita; Atsuko Araki; Ryu Miura; Yu Ait Bamai; Sumitaka Kobayashi; Sachiko Itoh; Kumiko Ito; Meng‐Shan Tsai; Reiko Kishi
• Keywords: Wheeze

Abstract Background A high dose of folic acid during pregnancy may increase the risk asthma, wheezing, and respiratory disease in childhood. Folate can modify inflammation immune susceptibility offspring with some epigenetic differentiation, including DNA methylation. This study evaluated associations between maternal folate levels childhood wheezing; furthermore, assessed whether folate‐modified methylation is related to asthma. Methods Participants current were 6651 mother‐child pairs who had complete data on characteristics completed at least one International Study Asthma Allergies Childhood questionnaires when child was 1, 2, 4, 7 years age. Moreover, a case‐control assess age conducted among 136 children experienced wheezing control group 139 no history allergies. Results The median serum 16.76 nmol/L, assayed by chemiluminescent immunoassay. We found significantly increased adjusted odds ratios 2 according levels, compared lowest quartile (odds ratio [95% confidence interval] = highest; 1.27 [1.03, 1.56], second, [1.05, 1.55]); however, changes observed In study, association observed. Conclusion Our results suggest that did not affect persistent school‐aged children, or gasdermin B, orosomucoid‐like 3, Ikaros family zinc finger 3