EAACIMolecular Allergology User's Guide 2.0

• DOI: 10.1111/pai.13854
• Publication Date: 2023-04-26T07:03:00Z
• Authors: Stephanie Dramburg; Christiane Hilger; Alexandra F. Santos; Leticia de las Ve...; Rob C. Aalberse; Nathalie Acevedo; Lorenz Aglas; Friedrich Altmann; Karla L. Arruda; Riccardo Asero; Barbara Ballmer‐W...; Domingo Barber; Kirsten Beyer; Tilo Biedermann; Maria Beatrice Bilo; Simon Blank; Philipp P. Bosshard; Heimo Breiteneder; Helen A. Brough; Merima Bublin; Dianne Campbell; Luis Caraballo; Jean Christoph Ca...; Giorgio Celi; Martin D. Chapman; Maksymilian Chruszcz; Adnan Custovic; Rebecca Czolk; Janet Davies; Nikolaos Douladiris; Bernadette Eberlein; Motohiro Ebisawa; Anna Ehlers; Philippe Eigenmann; Gabriele Gadermaier; Mattia Giovannini; Francisca Gomez; Rebecca Grohman; Carole Guillet; Christine Hafner; Robert G. Hamilton; Michael Hauser; Thomas Hawranek; Hans Jürgen Hoffmann; Thomas Holzhauser; Tomona Iizuka; Alain Jacquet; Thilo Jakob; Bente Janssen‐Weets; Uta Jappe; Marek Jutel; Tanja Kalic; Sandip Kamath; Sabine Kespohl; Jörg Kleine‐Tebbe; Edward Knol; André Knulst; Jon R. Konradsen; Peter Korošec; Annette Kuehn; Gideon Lack; Thuy‐My Le; Andreas Lopata; Olga Luengo; Mika Mäkelä; Alessandro Maria ...; Clare Mills; Martine Morisset; Antonella Muraro; Anna Nowak‐Wegrzyn; Roni Nugraha; Markus Ollert; Kati Palosuo; Elide Anna Pastor...; Sarita Ulhas Patil; Thomas Platts‐Mills; Anna Pomés; Pascal Poncet; Ekaterina Potapova; Lars K. Poulsen; Christian Radauer; Suzana Radulovic; Monika Raulf; Pierre Rougé; Joaquin Sastre; Sakura Sato; Enrico Scala; Johannes M. Schmid; Peter Schmid‐Gren...; Denise Schrama; Hélène Sénéchal; Claudia Traidl‐Ho...; Marcela Valverde‐...; Marianne van Hage; Ronald van Ree; Kitty Verhoeckx; Stefan Vieths; Magnus Wickman; Josefina Zakzuk; Paolo M. Matricardi; Karin Hoffmann‐So...
• Keywords: Gibberellin-regulated proteins; component-resolved diagnosis; Al·lèrgia - Tractament; Allergy; Seed storage proteins; [SDV]Life Sciences [q-bio]; Basophil activation test; seed storage proteins; Microarray; oleosins; profilins; cross-reactive carbohydrates; Profilins; :aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::isotipos de inmunoglobulinas::inmunoglobulina E [COMPUESTOS QUÍMICOS Y DROGAS]; info:eu-repo/classification/ddc/618; Immunology and Allergy; :Otros calificadores::/terapia [Otros calificadores]; parvalbumins; ddc:610; Hypersensitivity / diagnosis; polcalcins; atopic dermatitis; Tropomyosins; Research Support, Non-U.S. Gov't; Precision medicine; Immunoglobulina E; Hypersensitivity / therapy; General medicine, internal medicine and other clinical medicine; Aallergy; Lipocalins; 3. Good health; Parvalbumins; IgE; IgE cross-reactivity; allergy; allergy diagnosis; anaphylaxis; asthma; atopic dermatitis; basophil activation test; component-resolved diagnosis; cross-reactive carbohydrates; diagnostic algorithms; food allergy; gibberellin-regulated proteins; lipocalins; microarray; molecular allergology; non-specific lipid transfer proteins; oleosins; pan-allergens; parvalbumins; pathogenesis-related protein family 10; polcalcins; pollen allergy; precision medicine; profilins; seed storage proteins; serum albumins; tropomyosins; Pan-allergens; pan-allergens; IgE; Polcalcins; lipocalins; microarray; Non-specific lipid transfer proteins; Pathogenesis-related protein family 10; Component-resolved diagnosis; :Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin E [CHEMICALS AND DRUGS]; Serum albumins; Hypersensitivity/diagnosis; molecular allergology; Molecular allergology; precision medicine; Immunology; 610; gibberellin-regulated proteins; 618; Cross-reactive carbohydrates; tropomyosins; Research Support, N.I.H., Extramural; Allergy diagnosis; diagnostic algorithms; Diagnostic algorithms; Food allergy; pollen allergy; anaphylaxis; Journal Article; Hypersensitivity; Humans; Pediatrics, Perinatology, and Child Health; Anaphylaxis; Gynaecology and paediatrics; Atopic dermatitis; food allergy; :enfermedades del sistema inmune::hipersensibilidad [ENFERMEDADES]; :Immune System Diseases::Hypersensitivity [DISEASES]; :Other subheadings::/therapy [Other subheadings]; asthma; Allergens; Immunoglobulin E; pathogenesis-related protein family 10; allergy; Asthma; Oleosins; allergy diagnosis; IgE cross-reactivity; basophil activation test; non-specific lipid transfer proteins; Al·lèrgia - Diagnòstic; serum albumins; Pollen allergy

AbstractSince the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE‐mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well‐defined, highly pure molecules for component‐resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state‐of‐the‐art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.