Differences between adult and pediatric chronic spontaneous urticaria from a cohort of 751 patients: Clinical features, associated conditions and indicators of treatment response

• DOI: 10.1111/pai.13925
• Publication Date: 2023-02-23T13:27:39Z
• Authors: Deniz Özçeker; Pelin Kuteyla Can; Özlem Terzi; Sinem Ayşe Ornek; Ece Nur Değirmentepe; Kübra Kızıltac; Esra Sarac; Emek Kocatürk
• Keywords: Etiology; Omalizumab; Refractory (planetary science)

Abstract Background Chronic spontaneous urticaria (CSU) is a common disease both in the pediatric and adult population. However, there are differences between two patient populations with respect to etiological factors, comorbidities, treatment responses. Our aim was determine CSU terms of clinical characteristics, laboratory parameters, response treatment, indicators response. Methods A retrospective analysis patients performed. Data regarding were analyzed. Indicators determined separately patients. Results Of 751 (162 pediatrics 589 adults), female dominancy (48.8% vs. 69.6%) rate angioedema (19.1% 59.8%) lower, duration (5 months 12 months) shorter Anti‐TPO positivity (24.7% 9%), elevated CRP (46.5% 11.1%), eosinopenia (38.5% 18.1%), skin prick test (39.3% 28.8%) significantly more frequent Response antihistamines higher group, only 7% used omalizumab versus 20.8% adults. The comparisons also performed <12‐year ≥12‐year yielded similar results. Conclusion Pediatric shows distinct characteristics such as lower incidence antithyroid antibodies, it responds better antihistamines. These suggest that becomes severe refractory adolescents Adolescent features rather than CSU.