Limited clinical role of blood eosinophil levels in early life atopic disease: A mother–child cohort study

• DOI: 10.1111/pai.14050
• Publication Date: 2023-11-27T23:50:42Z
• Authors: Signe Kjeldgaard ...; Mathias Elsner Me...; Casper‐Emil Tings...; Luo Yang; Nilo Vahman; Jacob P. Thyssen; Ann‐Marie M. Schoos; Jakob Stokholm; Hans Bisgaard; Bo Chawes; Klaus Bønnelykke
• Keywords: Wheeze; Atopy

Blood eosinophil count is a well-established biomarker of atopic diseases in older children and adults. However, its predictive role for preschool not well established.To investigate the association between blood development up to age 6 years.We investigated at 18 months years relation recurrent wheeze/asthma, dermatitis, allergic rhinitis, sensitization during first life two Copenhagen Prospective Studies on Asthma Childhood cohorts (n = 1111). was with remission existing disease, current later disease.Blood associated wheezing/asthma or while increased occurrence (OR 1.1; 1.04-1.16, p .0005), dermatitis 1.06; 1.01-1.1, .02), rhinitis 1.11; 1.05-1.18, .0002). did predict persistence wheeze/asthma years.Blood disease. This implies limited clinical levels early-life disease questions value counts measured toddlers as subsequent early childhood.