Assessing the survival impact of perioperative opioid consumption in children and adolescents undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy
Male
Reoperation
Adolescent
Carcinoma
Infant
Antineoplastic Agents
Cytoreduction Surgical Procedures
Hyperthermia, Induced
Prognosis
Combined Modality Therapy
Disease-Free Survival
Perioperative Care
3. Good health
Analgesics, Opioid
03 medical and health sciences
0302 clinical medicine
Child, Preschool
Disease Progression
Humans
Pain Management
Female
Child
Peritoneal Neoplasms
DOI:
10.1111/pan.13146
Publication Date:
2017-04-17T07:27:42Z
AUTHORS (10)
ABSTRACT
SummaryBackgroundSeveral studies in adult patients have suggested an unfavorable association between opioid consumption and cancer progression.AimsThis study investigated the impact of opioid consumption on the survival of children and adolescents undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.MethodsA retrospective study of patients <19 years who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy was performed. Univariate and multivariate Cox proportional hazard analyses were used to identify factors associated with recurrence‐free survival and overall survival.ResultsSeventy‐five patients were identified. Median age was 11.6 years (range, 1.8–18.9), and 43% was female. Median perioperative opioid consumption was 18.9 morphine dose equivalents per kilogram (range, 0.6–339.6). There was no statistically significant association between opioid consumption and recurrence‐free survival [hazard ratio, 1.00; 95% confidence interval, (0.99–1.02), P = 0.55] or overall survival [hazard ratio 1.01; 95% confidence interval (0.99–1.03), P = 0.22]. Independent prognostic factors associated with poor survival included incomplete cytoreduction and extra‐abdominal disease.ConclusionIn this retrospective study of children and adolescents who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy, there was no statistically significant association between opioid consumption and recurrence‐free survival or overall survival.
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