Type I interferon signature in the initiation of the immune response in vitiligo

• DOI: 10.1111/pcmr.12219
• Publication Date: 2014-01-18T14:26:43Z
• Authors: Antoine Bertolotti; Katia Boniface; Beatrice Vergier; Djavad Mossalayi; Alain Taieb; Khaled Ezzedine; Julien Seneschal
• Keywords: Vitiligo; CXCR3; CXCL9

Summary Immune‐mediated responses are consistently observed in progressing vitiligo at the edge of depigmenting patches. Besides role adaptive immune system, profile innate response is now center stage. We report that plasmacytoid dendritic cells ( pDC ), which major interferon IFN )‐alpha‐producing cells, part infiltrate progressive with local production MxA (a protein induced by α ). was associated expression type I ‐inducible ligand CXCL 9 and correlated recruitment CXCR 3 + cells. Interestingly, strong perilesional skin close apposition to remaining melanocytes, surrounded a prominent T‐cell infiltrate. In contrast, not detectable lesional skin, suggesting ‐ an early event progression disease. Our data highlight new pathway leading vitiligo.