Type I interferon signature in the initiation of the immune response in vitiligo
Adult
Inflammation
Male
Myxovirus Resistance Proteins
0301 basic medicine
Receptors, CXCR3
Adolescent
Interferon-alpha
Dendritic Cells
Middle Aged
Chemokine CXCL9
Immunity, Innate
Autoimmune Diseases
3. Good health
Chemotaxis, Leukocyte
03 medical and health sciences
0302 clinical medicine
T-Lymphocyte Subsets
Disease Progression
Humans
Female
Nevus, Halo
Aged
Skin
DOI:
10.1111/pcmr.12219
Publication Date:
2014-01-18T14:26:43Z
AUTHORS (7)
ABSTRACT
SummaryImmune‐mediated responses are consistently observed in progressing vitiligo at the edge of depigmenting patches. Besides the role of the adaptive immune system, the profile of the innate immune response is now at the center of the stage. We report that plasmacytoid dendritic cells (pDC), which are the major interferon (IFN)‐alpha‐producing cells, are part of the infiltrate of progressive vitiligo with local production of MxA (a protein induced by IFNα). MxA was associated with expression of the type I IFN‐inducible ligand CXCL9 and correlated with the recruitment of CXCR3+ immune cells. Interestingly, strong MxA expression was observed in perilesional skin in close apposition to remaining melanocytes, surrounded by a prominent T‐cell infiltrate. In contrast, MxA was not detectable in lesional skin, suggesting that IFN‐α production is an early event in the progression of the disease. Our data highlight a new innate immune pathway leading to progression of vitiligo.
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